What's it about?
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This should give you a kinda clear idea http://myanimelist.net/anime/18277/Strike_the_Blood
Although, one or two things are misrepresented and missing from that description.
Ok, let me try giving you my explanation.
In this universe, demons and humnas co-exist. Demons & humans each have their own areas.
There exist, I would almost call them legendary demons. Demons with power far beyond that of any normal creature, in a sense most of them are witches and vampires.
The story is centered around Akatsuki Kojou who "received" his powers from one of these legendary vampires, making him known as the Fourth Progenitor.
Now basically there are different "police" type organisations who keep a watch over these area's/worlds, one is called the Lion King organisation (stupid name:p).
They send a young lady who wields one of the most powerful "divine/holy" weapons to observe this Progenitor and to make sure that he can be dealt with if need be.
Trouble, turmoil, destruction, fighting, various love interest and funny characters follow the series.
Its a really cool series, which I'm really looking forward to watching each week:D
I am digging soul eater. Love the intro so much they did it in such a way :D And the cat pumpkin pumpkin :p
So it's now quite anime (although it's in the style of) but I started watching Avatar: The Last Airbender, I'm enjoying it so far (1st four eps) it's actually quite relaxing being a kid again.
I'd be more specific and say it shares a lot with the Rosario + Vampire manga, rather than the anime. The R+V anime was a rather pointless harem romantic comedy with lots of fan-service and barely stuck to the manga at all, while the manga itself was considerably darker, and had much more action and plot development.
Basically, Strike the Blood is the anime that Rosario + Vampire should have been - harem and romance elements included.