If you go through all the side quests it'll feel horribly long :D
I think I did 31 or 32 hours on my first pass through.
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The main quest was short, but intense. The majority of the side quests were very generic and shallow. Almost as if they threw a few nouns and verbs in to a randomizer to generate the side quests.
Example:
Go to (Planet A/Planet B/Ship A), that uses (Map 1/Map 2), and kill a group of (Mercs/Husks/Biotics), then (Kill/Talk to/Activate) a (Character/Terminal).
What can I say? I was trying to complete all the challenges ;)
Listening to all the "incoming" messages was getting pretty tiresome after awhile though :/