My predictions:

Best Game Design

Between Mass Effect 2 and God of War III

Innovation

Minecraft or Limbo

Best Technology

Heavy Rain, Mass Effect 2 or God of War III

Best Audio

Limbo

Best Downloadable Game

Limbo or Super Meat Boy

Best Writing

Red Dead Redemption or Heavy Rain

Best Debut Game

Limbo

Best Visual Arts

God of War III or Limbo

Game of the Year

Mass Effect 2 or Limbo