I knew it, I suppose there was once, but it's very difficult to find in todays world as originality is generally shot down. We all must conform we are the borg is what happens, it's why there are some many shows about Vampires, why similar movies get released at almost the same time etc...
Especially when you consider the OP's original statement a game pulling nothing from anything else that has ever existed type statement, there is therefore no original games as they all pull from something ;-)
Live Long and Prosper
Metal gear
The orginal one from 1987
http://en.m.wikipedia.org/wiki/Metal_Gear_(video_game)
Day of the Tentacle
Find a game as awesome an original as this >.<