Invasion type scifi's could work, but it's possible they may fail since it's kinda Half-Life territory
District 9 as a game could work. Watching it felt very game like in itself. Cloverfield maybe.....maybe not.
Also, a lot of stories that sucked in movie form, may do better in game format where it could be fleshed out better. Skyline and Darkest Hour kinda sucked as movies. The concepts were kinda cool, but wasn't brought across well enoguh. 90% of Skyline was like "er...get to the point already...is this a sci fi or bad-line contest", and then in the last 10 minute's I was like "WTH didn't they do this 60min's ago. Darkest hour was so haphazardly done, at the end you were like, "huh what...is that it?". Characters seemed.....empty, in the movie.