Already mentioned, but Papo & Yo fits the bill for a much different gaming experience. I really liked it though.
I love these type of games, and I've got quite a few Indies in my gaming lists of various platforms. FEZ, FTL, LIMBO, Bastion, Banished and Skydrift are all games I would also add to this list.
Another game I would see as "off the beaten path" is Euro Truck Simulator. It's really good and relaxing
