I haven't gotten around to playing most of the new games, but Witcher 2 and Portal 2 should both definitely win in at least one of the categories. Witcher 2 was just stunning and Portal 2's multiplayer was loads of fun. Haven't played the new Assassins Creed or Batman yet, but based on the previous games alone, I'll vote for both of them as well to win in at least one category.
For Best RPG, I'm yet to play Deus Ex (got it yesterday... didn't even know it is a RPG) and haven't tried Skyrim so I'll have to vote for DA2 which I'm busy with in my 2nd playthrough... Great game albeit a bit extreme.
And of course, most anticipated game for me would be Mass Effect 3. It has been since ME2.