This is not easy, you should try different combo's.
Some people set their wasd keys to the center of the kb. I use standard wasd, then shift for run, ctrl for toggle crouch prone. And dont forget your lean buttons q and e
Wheel up for reload, wheel down for weapon switch, middle mouse for grenade, Thumb(mouse4) for Knife, Thumb(mouse5) for flashbang. Standard right click toggle aim and left click fire. I play different fps games and set all the settings the same in everygame.
+1.. I play pretty much the same as you, I dont use ctrl for crouch/prone though, those are usually setup on z,x,c...
Other than that its pretty much standard controls. WASD, Shift(sprint/steady aim), Space(jump), mouse for throwing grenade, aiming, firing, mouse button 4/5 for knife etc...
As for the actual gameplay, I haven't played blops2 but its probably the same as all the others in the genre,
my suggestion is pick a gun that you see is killing you most of the time and try that gun, if you enjoy it stick with it until you have learnt how the game engine works and once you have learnt the maps back to front. Get used to the way the guns feel when you fire, a lot of the time its better to fire one bullet at a time, it lands up being more accurate and generally you land up killing more than just random spray and pray.
Use places for cover, try not stand in the open unless you are used to the game engine and have the confidence to just run around in the open. another useful tip is to PRACTICE. spending time playing the game will ultimately get you to a better playing level.
The most important of all factors though is to enjoy the game!