Loved Evil Genius. Wish they could have polished it a bit more though, quite a few bugs in it.
Also check out Startopia. It's one of those games that I play through at least once a year or so. Lots of Hitchhikers Guide to the Galaxy type humour. Even has the narrator from the radio series in it.
Tiledmill from the guys that worked on Caesar III, Pharaoh, Zeus, Children of the Nile and Caesar IV are announcing a new city builder. Medieval Mayor. http://tiltedmill.com/medieval-mayor/
Children of the Nile & Ceasar IV disappointed me. Here's to hoping they can pull their heads out of their arses. I wonder if we're going to see a kickstarter for this...
More of a question here, but I'm trying to play Afterlife. The problem is, on Win7 the tutorial just locks up, so I can't actually figure out how to play the game. Anyone here ever try playing the game and did you find a fix for it? Google isn't bringing up any solutions.